Feline lymphoma is one of the most frequently diagnosed tumors in cats. Lipotropes are dietary methyl donors that may modulate DNA methylation status and the expression of genes involved in growth and apoptosis of feline lymphoma cells. The specific objective of the study was to determine if lipotropes affect the growth of feline lymphoma cells, which entailed examining a correlation between lymphoma cell proliferation and apoptosis.
F1B and FeLV-3281 cells were cultured and treated with 20 times the level of lipotropes contained in the basal culture medium. Cell growth and death and caspase 3 and tumor protein p53 activity were measured. Lipotropes were found to significantly reduce cell growth and increase cell death. Caspase 3 and p53 activity was seen in F1B cells after 72 hours, but the effect was minimal on FeLV-3281.
These results could be useful in the development of dietary strategies for treating and preventing feline lymphoma.
Source: L. Mabasa et al., 2012. Lipotropes (methyl nutrients) inhibit growth of feline lymphoma in vitro. Res Vet Sci 93: 259-263. doi: 10.1016/j.rvsc.2011.05.015
The top 10 petfood manufacturers continue to feel the effects of the global economic meltdown
The maker of raw and holistic diets seeks to help transform pets through its products, philosophy, education and research
This book takes a decidedly different turn from the usual consumer-oriented petfood fodder
What is this quiet, unassuming ingredient, and should it be there?
The lowly pea appears to be an effective ingredient for the next generation of dog and cat diets
5 small steps would streamline information on petfood ingredients to help communicate with pet owners
--- Thank you for your patience ----
If you have any issues logging in or any other need feel free to contact us.